WebApr 10, 2024 · Liver fibrosis and hepatocellular carcinogenesis secondary to liver fibrosis are serious liver diseases with no effective treatments. Mori fructus aqueous extracts (MFAEs) have served as successful treatments for many types of liver injury including fibrosis although the molecular mechanisms are unknown at present. To investigate the … WebMay 21, 2006 · Aim: To evaluate serum TIMP-1 level and the correlation between TIMP-1 expression and liver fibrosis in immune-induced and CCL4-induced liver fibrosis models …
Towards a standard diet-induced and biopsy-confirmed mouse …
WebAim: The optimal screening strategy for advanced liver fibrosis in overweight and obese patients is unknown. ... such as tissue metallopeptidase inhibitor 1 (TIMP1; P = 0.011), poly[ADP-ribose]polymerase 1 (PARP1, P = 0.034), and WNT1-inducible-signaling pathway protein 1 (WISP1, P = 0.05), apoptosis (caspase 7, ... Heart disease continues to be a major cause of morbidity and mortality worldwide. According to a recent report from American Heart Association, death caused by cardiovascular diseases accounts for 1 in every 3 deaths in North America.1 Fibrosis is a common feature of various cardiomyopathies including … See more Tissue fibrosis is a key pathogenic feature of end-organ failure in various organs, including heart failure. This study reveals a new function for … See more Our study defines a novel and MMP-independent function for TIMP1 in inducing myocardial fibrosis through mediating an interaction between CD63 and integrin β1 on cardiac fibroblasts that leads to de novo … See more tinnitus when turning head
Meritxell Perramón, PhD - Postdoctoral Researcher - Institut d ...
WebMar 14, 2024 · Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease associated with high mortality [].Two anti-fibrotic agents, nintedanib and pirfenidone, have been approved for the treatment of IPF and demonstrated to slow the progression of the disease [2, 3].However, the diagnosis and management of IPF remain challenging, with no … WebFeb 1, 2024 · Collagen metabolism in VMC rats was restrained by BMSC modified with ADAMTS-1 inhibitor and therefore the myocardial fibrosis was ameliorated with the possible mechanism being through regulation of the TGFβ1/MMP9/TIMP1 signaling pathway. This study assesses the mechanism of BMSC modified with ADAMTS-1 inhibitor in regulating … WebThis study assesses the mechanism of BMSC modified with ADAMTS-1 inhibitor in regulating the myocardial fibrosis in myocarditis through TGFβ1/MMP9/TIMP1 pathway and collagen metabolism.Model of viral myocarditis (VMC) rats was established and then assigned into control set, carrier set, inhibitor set and carrier and inhibitor set randomly … passing volatile as this