Pim1 and p53
WebJun 15, 2024 · Both PIM-1 and PIM-2 share 61% idleness whereas the PIM1 and PIM3 showed 71% similarity [2]. ... The p53 acts as a tumor suppressor gene, which activates the expression of various target genes that mediate the p53 responses. In different stress conditions, p53 accumulates in cells and responsible for cell cycle arrest, apoptosis, and … WebFeb 9, 2010 · Phosphorylation of PIM1 on Tyr218 by the ETK tyrosine kinase was required for IL-6-induced activation of androgen receptor-mediated transcription.26,27As PIM proteins harbor over 35 potential recognition sites for a large variety of kinases, the impact of PIM autophosphorylation or heterologous phosphorylation by upstream regulators for …
Pim1 and p53
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WebPim1/Targets/FAQ/Targets/MDM-2, p53 related products. MedChemExpress provides thousands of inhibitors, modulators and agonists with high purity and quality, excellent customer reviews, precise and professional product citations, tech … WebJul 20, 2010 · To generate cells expressing PIM1 and p53 wild-type proteins, 22Rv1 stable cell lines with inducible PIM1 expression or a vector control were transfected with p53-GFP plasmid using TransIT-Prostate transfection kit (Mirus) according to the manufacturer's protocol. Cells were selected with G418 (400 μg/mL) for 14 days and individual clones …
WebJun 12, 2014 · PIM1 kinase is overexpressed in many tumor types including lymphomas and prostate cancer, where it is known to cooperate with the MYC oncogene in promoting tumorigenicity. PIM1 has emerged as an attractive target for drug discovery, but few PIM1 inhibitors have been tested in vitro or in vivo. WebFeb 1, 2008 · Both p53 and p53-dependent factors are unaffected by KLF5 depletion. Instead, the apoptotic phenotype consequent to damage is associated with reduced bad phosphorylation, and downregulation of Pim1.
WebPim1/Targets/FAQ/Targets/MDM-2, p53 related products. MedChemExpress provides thousands of inhibitors, modulators and agonists with high purity and quality, excellent … WebApr 29, 2016 · Pim1 promoter luciferase activity assay in mutant P53 (N340Q/L344R) overexpressed HepG2 cell lines. Each value was presented as mean±standard error of the mean (SEM). D. pim1 expression...
WebJun 12, 2012 · The University of Texas MD Anderson Cancer Center. 1997 - Present26 years. Houston, Texas Area. Focus on cancer research in cell cycle, DNA damage and signal transduction. Biochemist, Molecular ...
WebNuc-Pim1 enhances stem cell youthfulness associated with decreased senescence-associated β-galactosidase activity, preserved telomere length, reduced expression of p16 and p53, and up-regulation ... thv chemicals dying lightWebOct 1, 2016 · Mutant P53 (N340Q/L344R) enhances Pim1 expression triggered by the increased interplay between H3K9me1 and HP1α. To prove whether Mutant P53 (N340Q/L344R) enhanced the Pim1 expression in liver cancer cells Hep3B, we first prefromed Chromatin -Immunoprecipitation (CHIP) with anti-H3K9me1 and anti-HP1α. thv compoundWebNov 17, 2011 · Several lines of evidence suggest that PIM1 and PIM2 may be involved in DLBCL pathogenesis; PIM1 has been described as a target for aberrant somatic hypermutation in DLBCL, 28 whereas PIM1 and PIM2 expression distinguish the ABC-DLBCL subtype. 3 Consequently, we decided to explore PIM kinases as candidate therapeutic … thv cotuWebAug 26, 2024 · A powerful genetic predictive model (AUROC = 0.771, 95% CI: 0.689–0.853) incorporating lactate dehydrogenase levels (OR = 2.990, p = 0.018), CD79B mutations (OR = 5.970, p = 0.001), and PIM1 mutations (OR = 3.021, p = … thvd 1450WebNuc-Pim1 successfully alters senescence-associated phenotypic characteristics relative to PimWT and Mito-Pim1 overexpression; significant blunting of hCPC senescence was shown by a 30% decrease in SA β-gal positivity, restoration to a youthful morphology, suppression of senescent markers p16 and p53, and the ability to undergo several ... thv coralWebAug 1, 2010 · Lastly, PIM1 mutations were significantly linked with p53 high DLBCL with SSP. This gene has a wellcharacterised role in cell survival and is seen as a proto-oncogene acting synergistically... thvd1424WebApr 29, 2024 · PIM1, PIM2 and PIM3 proteins were expressed in HCC827, H460 and H1975 cell lines as determined by Western blot analysis. The anti-PIM1 (C93F2) antibody was … thvd1424rgtr