WebJul 1, 2016 · The BAFF cytokine as a protein. BAFF is a type II transmembrane protein of 285 amino acids, with a cytoplasmic domain of 46 amino acids, characterized by being rich in cysteine in its ligand binding region, a transmembrane hydrophobic region and a domain of 218 amino acids that contain 2 potential sites of N-glycosylation. WebCD40 ligand (CD40L) and B-cell activating factor (BAFF) play important roles in the function of B cells. However, the difference of their regulatory effects remains obscure. In this study, we used anti-CD40 to imitate CD40L and investigated the different regulatory effects of CD40L and BAFF on the f …
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WebApr 16, 2012 · Cytokine BAFF (also known as B-cell activating factor), is a member of TNF superfamily ligand that is expressed on the cell surface or cleaved and secreted. … WebBAFF (B lymphocyte activating factor of the tumour necrosis factor family) is a vital homeostatic cytokine for B cells that helps regulate both innate and adaptive immune responses. Increased serum levels of BAFF are found in a number of different autoimmune diseases, and BAFF is found in inflammato … how to scrobble youtube music
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WebThe BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is … WebJul 29, 2024 · In patients with severe COPD, tertiary lymphoid follicles containing B lymphocytes and B cell-activating factor (BAFF) overexpression are associated with disease severity. ... This demonstrates that BAFF is a key proinflammatory cytokine and that innate immune cells in particular neutrophils, are an unconsidered source of BAFF in early … WebSamples were stored at −80°C until the assays were performed. The same procedure was performed for the control patients. The cytokine/chemokines concentrations, including IL-6, IL-10, IL-17, CXCL12, CXCL13, BAFF and HMGB1, were measured by enzyme-linked immunosorbent assays (ELISAs) using human ELISA kits (Abcam, Cambridge, UK). how to scrobble soundcloud