Cisplatin clearance
WebThe mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and 50 mL/min/m2 following administration of 100 mg/m2 as 2-hour or 6- to 7-hour infusions, … WebSep 21, 2024 · Use of cisplatin therapy is associated with reduced total body clearance. In children, elevated serum SGPT levels are associated with reduced drug total body clearance. Prior use of cisplatin may also …
Cisplatin clearance
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WebCISPLATIN is a chemotherapy drug. It targets fast dividing cells, like cancer cells, and causes these cells to die. This medicine is used to treat many types of cancer like … WebSep 21, 2016 · In 25 patients assessable for both courses, the use of a fixed dose of cisplatin resulted in reduced exposure to unbound platinum in patients at the upper extremes of BSA (P = .003) and higher exposures in patients at the lower extremes (P = .009), as compared with exposures following the BSA-adjusted dose.Although clearance …
WebThe intraperitoneal injection of cisplatin increased kidney weight, serum cystatin-c, and serum creatinine, at the same time, decreased body weight, urinary volume, urine creatinine, creatinine clearance, and renal antioxidant activity, all of which were significant. WebThe mean renal clearance of cisplatin exceeds creatinine clearance and is 62 and 50 mL/min/m. 2 following administration of 100 mg/m as 2-hour or 6- to 7-hour infusions, …
WebSep 15, 2024 · Cisplatin is a prescription medicine used to treat the symptoms of cancer in the testicles (Metastatic Testicular Tumors), bladder (Advanced Bladder Cancer) and … WebFeb 16, 2024 · This drug should be administered by slow IV infusion. Do not give by rapid IV infusion. Pretreatment hydration with 1 to 2 liters of fluid infused for 8 to 12 hours …
WebClearance of cisplatin, etoposide, and ifosfamide depends on kidney function and dosages should be adjusted in patients with renal impairment. However, there is still limited data on the adherence of physicians to dosing recommendations for these drugs in cancer patients with renal impairment.
WebMar 9, 2024 · Currently, societies of nephrology recommend dose reductions in cisplatin for patients with renal insufficiency of creatinine clearance (CrCl) between 30 and 60 mL/min. 10-12 Among their recommendations, unified protocol based on Kintzel's indication is especially popular. 10, 11, 13 Kintzel et al reported an indicator of cisplatin dose ... cityfit blue bydgoszcz fordonWebThe effect is dose-dependent at oral doses between 600 and 1800 mg/day in patients with normal kidney clearance. 66 ESRD patients may require higher doses (5 mg) and several studies have provided NAC intravenously to these … cityfit cennikWebMay 18, 2024 · Compared with nonelderly patients, elderly patients (older than 70 years) have slow ultrafilterable cisplatin plasma clearance and persistently high plasma levels of ultrafilterable cisplatin at 48 h after receiving an initial dose of 50–65 mg/m 2. 81 A dose of 80 mg/m 2 cisplatin was administered to patients with lung cancer, and the results … city fit bundabergWebFor research use only. Cisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by conforming DNA … city fit bonnWebCisplatin is a clinically advanced and highly effective anticancer drug that is used for the treatment of various solid tumors, such as lung cancer, stomach cancer, and ovarian cancer [ 1 ].... dictreader\u0027 object has no attribute nextWebALIMTA in combination with cisplatin is indicated for the treatment of chemotherapy naïve patients with unresectable malignant pleural mesothelioma. ... creatinine clearance of ≥ 45 ml/min required no dose adjustments other than those recommended for all patients. There are insufficient data on the use of pemetrexed in patients with ... cityfit cateringWebFeb 16, 2016 · All patients were treated with high-dose cisplatin CCRT. The main outcome parameters were nephrotoxicity (defined as creatinine clearance grade 2 or more) and cumulative doses of cisplatin and radiation. Results: 133 patients (64%) completed all pre-planned courses of cisplatin. Nephrotoxicity was the main reason to discontinue the … cityfit cena